Liposomal Delivery Systems: Design Optimization and Current Applications
نویسندگان
چکیده
منابع مشابه
Liposomal drug delivery systems--clinical applications.
Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. As a result, numerous improvements have been made, thus making this technology potentially useful for the treatment of certain diseases in the clinics. The success of liposomes as drug carriers has been reflected in a number of liposome-based formul...
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The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and soon were proposed as drug delivery systems. The pioneering work of countless liposome researchers over almost 5 decades led to the development of important technical advances such as remote drug loading, extrusion for homogeneous size, long-circulating (PEGylated) liposomes, triggered release liposomes,...
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Recently a number of lipid based systems like lipospheres, liposomes, niosomes, ethosomes, and transferosomes have been developed. The purpose of this review article on colloidosome drug delivery was to compile the focus on the types, properties, fabrication techniques, characterization and stability of colloidosomes. This system also solves the problem of insolubility, instability, rapid degra...
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Despite of its effective anti-tumour activity,L-Asparaginase has limited clinical application due to the high rate of clinical hypersensitivity. In an attempt to develop a liposomal drug delivery for L-Asparaginase, enzyme loaded liposomes were formulated using soy lecithin, cholesterol and charge inducers by thin film hydration method. The effect of various components of the liposomes includin...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2017
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b16-00624